Author Moll, Ute M.

1 to 20 of 29 Items
  • 2021 Journal Article | Research Paper | 
    ​ ​Suppression of HSF1 activity by wildtype p53 creates a driving force for p53 loss-of-heterozygosity​
    Isermann, T.; Şener, Ö. Ç.; Stender, A.; Klemke, L.; Winkler, N.; Neesse, A. & Li, J. et al.​ (2021) 
    Nature Communications12(1) art. 4019​.​ DOI: https://doi.org/10.1038/s41467-021-24064-1 
    Details  DOI 
  • 2018 Journal Article | 
    ​ ​Gain-of-Function (GOF) Mutant p53 as Actionable Therapeutic Target​
    Schulz-Heddergott, R. & Moll, U. M.​ (2018) 
    Cancers10(6).​ DOI: https://doi.org/10.3390/cancers10060188 
    Details  DOI  PMID  PMC 
  • 2017 Journal Article | 
    ​ ​Strong antitumor synergy between DNA crosslinking and HSP90 inhibition causes massive premitotic DNA fragmentation in ovarian cancer cells​
    Kramer, D.; Stark, N. ; Schulz-Heddergott, R.; Erytch, N.; Edmunds, S.; Rossmann, L.   & Bastians, H. et al.​ (2017) 
    Cell Death and Differentiation24(2) pp. 300​-316​.​ DOI: https://doi.org/10.1038/cdd.2016.124 
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  • 2017 Journal Article | 
    ​ ​p53 loss-of-heterozygosity is a necessary prerequisite for mutant p53 stabilization and gain-of-function in vivo​
    Alexandrova, E. M.; Mirza, S. A.; Xu, S.; Schulz-Heddergott, R.; Marchenko, N. D. & Moll, U. M.​ (2017) 
    Cell Death and Disease8 art. e2661​.​ DOI: https://doi.org/10.1038/cddis.2017.80 
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  • 2017 Review
    ​ ​Mdm2 as a chromatin modifier​
    Wienken, M.; Moll, U. M.& Dobbelstein, M. ​ (2017)
    Journal of Molecular Cell Biology, 9​(1) pp. 74​-80​.​
    Oxford Univ Press. DOI: https://doi.org/10.1093/jmcb/mjw046 
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  • 2016 Journal Article
    ​ ​TAp73 is a central transcriptional regulator of airway multiciliogenesis​
    Nemajerova, A.; Kramer, D.; Siller, S. S.; Herr, C.; Shomroni, O.; Pena, T. & Suazo, C. G. et al.​ (2016) 
    Genes & Development30(11) pp. 1300​-1312​.​ DOI: https://doi.org/10.1101/gad.279836.116 
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  • 2016 Journal Article
    ​ ​MDM2 Associates with Polycomb Repressor Complex 2 and Enhances Stemness-Promoting Chromatin Modifications Independent of p53​
    Wienken, M.; Dickmanns, A.; Nemajerova, A.; Kramer, D.; Najafova, Z.; Weiss, M. & Karpiuk, O. et al.​ (2016) 
    Molecular Cell61(1) pp. 68​-83​.​ DOI: https://doi.org/10.1016/j.molcel.2015.12.008 
    Details  DOI  PMID  PMC  WoS 
  • 2015 Journal Article | 
    ​ ​Improving survival by exploiting tumour dependence on stabilized mutant p53 for treatment​
    Alexandrova, E. M.; Yallowitz, A. R.; Li, D.; Xu, S.; Schulz, R.; Proia, D. A. & Lozano, G. et al.​ (2015) 
    Nature523(7560) pp. 352​-+​.​ DOI: https://doi.org/10.1038/nature14430 
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  • 2014 Journal Article
    ​ ​TAp73 is essential for germ cell adhesion and maturation in testis​
    Holembowski, L.; Kramer, D. ; Riedel, D.; Sordella, R.; Nemajerova, A.; Dobbelstein, M.   & Moll, U. M.​ (2014) 
    The Journal of Cell Biology204(7) pp. 1173​-1190​.​ DOI: https://doi.org/10.1083/jcb.201306066 
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  • 2014 Journal Article | 
    ​ ​HER2/ErbB2 activates HSF1 and thereby controls HSP90 clients including MIF in HER2-overexpressing breast cancer​
    Schulz, R.; Streller, F.; Scheel, A. H.; Rueschoff, J.; Reinert, M. C.; Dobbelstein, M.   & Marchenko, N. D. et al.​ (2014) 
    Cell Death and Disease5 art. e980​.​ DOI: https://doi.org/10.1038/cddis.2013.508 
    Details  DOI  PMID  PMC  WoS 
  • 2014 Review
    ​ ​Targeting the heat shock protein 90: a rational way to inhibit macrophage migration inhibitory factor function in cancer​
    Schulz, R.& Moll, U. M.​ (2014)
    Current Opinion in Oncology, 26​(1) pp. 108​-113​.​
    Lippincott Williams & Wilkins. DOI: https://doi.org/10.1097/CCO.0000000000000036 
    Details  DOI  PMID  PMC  WoS 
  • 2014 Journal Article
    ​ ​Targeting tumour-supportive cellular machineries in anticancer drug development​
    Dobbelstein, M.   & Moll, U. M.​ (2014) 
    Nature Reviews Drug Discovery13(3) pp. 179​-196​.​ DOI: https://doi.org/10.1038/nrd4201 
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  • 2012 Journal Article
    ​ ​HSP90 inhibitor antagonizing MIF The specifics of pleiotropic cancer drug candidates​
    Schulz, R.; Dobbelstein, M.   & Moll, U. M.​ (2012) 
    OncoImmunology1(8) pp. 1425​-1426​.​ DOI: https://doi.org/10.4161/onci.21173 
    Details  DOI  WoS 
  • 2012 Journal Article | 
    ​ ​Inhibiting the HSP90 chaperone destabilizes macrophage migration inhibitory factor and thereby inhibits breast tumor progression​
    Schulz, R.; Marchenko, N. D.; Holembowski, L.; Fingerle-Rowson, G.; Pesic, M.; Zender, L. & Dobbelstein, M.  et al.​ (2012) 
    Journal of Experimental Medicine209(2) pp. 275​-289​.​ DOI: https://doi.org/10.1084/jem.20111117 
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  • 2012 Journal Article
    ​ ​p53 Opens the Mitochondrial Permeability Transition Pore to Trigger Necrosis​
    Vaseva, A. V.; Marchenko, N. D.; Ji, K.; Tsirka, S. E.; Holzmann, S. & Moll, U. M.​ (2012) 
    Cell149(7) pp. 1536​-1548​.​ DOI: https://doi.org/10.1016/j.cell.2012.05.014 
    Details  DOI  PMID  PMC  WoS 
  • 2012 Review
    ​ ​Role of p53 family members p73 and p63 in human hematological malignancies​
    Alexandrova, E. M.& Moll, U. M.​ (2012)
    Leukemia & Lymphoma, 53​(11) pp. 2116​-2129​.​
    Taylor & Francis Ltd. DOI: https://doi.org/10.3109/10428194.2012.684348 
    Details  DOI  PMID  PMC  WoS 
  • 2011 Journal Article
    ​ ​Endogenous retrovirus drives hitherto unknown proapoptotic p63 isoforms in the male germ line of humans and great apes​
    Beyer, U.; Moll-Rocek, J.; Moll, U. M. & Dobbelstein, M. ​ (2011) 
    Proceedings of the National Academy of Sciences of the United States of America108(9) pp. 3624​-3629​.​ DOI: https://doi.org/10.1073/pnas.1016201108 
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  • 2011 Journal Article
    ​ ​Functional Inactivation of Endogenous MDM2 and CHIP by HSP90 Causes Aberrant Stabilization of Mutant p53 in Human Cancer Cells​
    Li, D.; Marchenko, N. D.; Schulz, R.; Fischer, V.; Velasco-Hernandez, T.; Talos, F. & Moll, U. M.​ (2011) 
    Molecular Cancer Research9(5) pp. 577​-588​.​ DOI: https://doi.org/10.1158/1541-7786.MCR-10-0534 
    Details  DOI  PMID  PMC  WoS 
  • 2011 Journal Article
    ​ ​While p73 is essential, p63 is completely dispensable for the development of the central nervous system​
    Holembowski, L.; Schulz, R.; Talos, F.; Scheel, A.; Holzman, S.; Dobbelstein, M.   & Moll, U. M.​ (2011) 
    Cell Cycle10(4) pp. 680​-689​.​ DOI: https://doi.org/10.4161/cc.10.4.14859 
    Details  DOI  PMID  PMC  WoS 
  • 2010 Journal Article | 
    ​ ​Loss of p73 promotes dissemination of Myc-induced B cell lymphomas in mice​
    Nemajerova, A.; Petrenko, O.; Truemper, L. H.; Palacios, G. & Moll, U. M.​ (2010) 
    Journal of Clinical Investigation120(6) pp. 2070​-2080​.​ DOI: https://doi.org/10.1172/JCI40331 
    Details  DOI  PMID  PMC  WoS 

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