Author Moll, Ute M.
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2021 | Journal Article | Research Paper |
Suppression of HSF1 activity by wildtype p53 creates a driving force for p53 loss-of-heterozygosity
Isermann, T.; Şener, Ö. Ç.; Stender, A.; Klemke, L.; Winkler, N.; Neesse, A. & Li, J. et al. (2021)
Nature Communications, 12(1) art. 4019. DOI: https://doi.org/10.1038/s41467-021-24064-1
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2018 | Journal Article |
Gain-of-Function (GOF) Mutant p53 as Actionable Therapeutic Target
Schulz-Heddergott, R. & Moll, U. M. (2018)
Cancers, 10(6). DOI: https://doi.org/10.3390/cancers10060188
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2017 | Journal Article |
Strong antitumor synergy between DNA crosslinking and HSP90 inhibition causes massive premitotic DNA fragmentation in ovarian cancer cells
Kramer, D.; Stark, N. ; Schulz-Heddergott, R.; Erytch, N.; Edmunds, S.; Rossmann, L. & Bastians, H. et al. (2017)
Cell Death and Differentiation, 24(2) pp. 300-316. DOI: https://doi.org/10.1038/cdd.2016.124
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2017 | Journal Article |
p53 loss-of-heterozygosity is a necessary prerequisite for mutant p53 stabilization and gain-of-function in vivo
Alexandrova, E. M.; Mirza, S. A.; Xu, S.; Schulz-Heddergott, R.; Marchenko, N. D. & Moll, U. M. (2017)
Cell Death and Disease, 8 art. e2661. DOI: https://doi.org/10.1038/cddis.2017.80
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2017 | Review
Mdm2 as a chromatin modifier
Wienken, M.; Moll, U. M.& Dobbelstein, M. (2017)
Journal of Molecular Cell Biology, 9(1) pp. 74-80.
Oxford Univ Press. DOI: https://doi.org/10.1093/jmcb/mjw046
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2016 | Journal Article
TAp73 is a central transcriptional regulator of airway multiciliogenesis
Nemajerova, A.; Kramer, D.; Siller, S. S.; Herr, C.; Shomroni, O.; Pena, T. & Suazo, C. G. et al. (2016)
Genes & Development, 30(11) pp. 1300-1312. DOI: https://doi.org/10.1101/gad.279836.116
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2016 | Journal Article
MDM2 Associates with Polycomb Repressor Complex 2 and Enhances Stemness-Promoting Chromatin Modifications Independent of p53
Wienken, M.; Dickmanns, A.; Nemajerova, A.; Kramer, D.; Najafova, Z.; Weiss, M. & Karpiuk, O. et al. (2016)
Molecular Cell, 61(1) pp. 68-83. DOI: https://doi.org/10.1016/j.molcel.2015.12.008
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2015 | Journal Article |
Improving survival by exploiting tumour dependence on stabilized mutant p53 for treatment
Alexandrova, E. M.; Yallowitz, A. R.; Li, D.; Xu, S.; Schulz, R.; Proia, D. A. & Lozano, G. et al. (2015)
Nature, 523(7560) pp. 352-+. DOI: https://doi.org/10.1038/nature14430
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2014 | Journal Article
TAp73 is essential for germ cell adhesion and maturation in testis
Holembowski, L.; Kramer, D. ; Riedel, D.; Sordella, R.; Nemajerova, A.; Dobbelstein, M. & Moll, U. M. (2014)
The Journal of Cell Biology, 204(7) pp. 1173-1190. DOI: https://doi.org/10.1083/jcb.201306066
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2014 | Journal Article |
HER2/ErbB2 activates HSF1 and thereby controls HSP90 clients including MIF in HER2-overexpressing breast cancer
Schulz, R.; Streller, F.; Scheel, A. H.; Rueschoff, J.; Reinert, M. C.; Dobbelstein, M. & Marchenko, N. D. et al. (2014)
Cell Death and Disease, 5 art. e980. DOI: https://doi.org/10.1038/cddis.2013.508
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2014 | Review
Targeting the heat shock protein 90: a rational way to inhibit macrophage migration inhibitory factor function in cancer
Schulz, R.& Moll, U. M. (2014)
Current Opinion in Oncology, 26(1) pp. 108-113.
Lippincott Williams & Wilkins. DOI: https://doi.org/10.1097/CCO.0000000000000036
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2014 | Journal Article
Targeting tumour-supportive cellular machineries in anticancer drug development
Dobbelstein, M. & Moll, U. M. (2014)
Nature Reviews Drug Discovery, 13(3) pp. 179-196. DOI: https://doi.org/10.1038/nrd4201
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2012 | Journal Article
HSP90 inhibitor antagonizing MIF The specifics of pleiotropic cancer drug candidates
Schulz, R.; Dobbelstein, M. & Moll, U. M. (2012)
OncoImmunology, 1(8) pp. 1425-1426. DOI: https://doi.org/10.4161/onci.21173
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2012 | Journal Article |
Inhibiting the HSP90 chaperone destabilizes macrophage migration inhibitory factor and thereby inhibits breast tumor progression
Schulz, R.; Marchenko, N. D.; Holembowski, L.; Fingerle-Rowson, G.; Pesic, M.; Zender, L. & Dobbelstein, M. et al. (2012)
Journal of Experimental Medicine, 209(2) pp. 275-289. DOI: https://doi.org/10.1084/jem.20111117
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2012 | Journal Article
p53 Opens the Mitochondrial Permeability Transition Pore to Trigger Necrosis
Vaseva, A. V.; Marchenko, N. D.; Ji, K.; Tsirka, S. E.; Holzmann, S. & Moll, U. M. (2012)
Cell, 149(7) pp. 1536-1548. DOI: https://doi.org/10.1016/j.cell.2012.05.014
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2012 | Review
Role of p53 family members p73 and p63 in human hematological malignancies
Alexandrova, E. M.& Moll, U. M. (2012)
Leukemia & Lymphoma, 53(11) pp. 2116-2129.
Taylor & Francis Ltd. DOI: https://doi.org/10.3109/10428194.2012.684348
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2011 | Journal Article
Endogenous retrovirus drives hitherto unknown proapoptotic p63 isoforms in the male germ line of humans and great apes
Beyer, U.; Moll-Rocek, J.; Moll, U. M. & Dobbelstein, M. (2011)
Proceedings of the National Academy of Sciences of the United States of America, 108(9) pp. 3624-3629. DOI: https://doi.org/10.1073/pnas.1016201108
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2011 | Journal Article
Functional Inactivation of Endogenous MDM2 and CHIP by HSP90 Causes Aberrant Stabilization of Mutant p53 in Human Cancer Cells
Li, D.; Marchenko, N. D.; Schulz, R.; Fischer, V.; Velasco-Hernandez, T.; Talos, F. & Moll, U. M. (2011)
Molecular Cancer Research, 9(5) pp. 577-588. DOI: https://doi.org/10.1158/1541-7786.MCR-10-0534
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2011 | Journal Article
While p73 is essential, p63 is completely dispensable for the development of the central nervous system
Holembowski, L.; Schulz, R.; Talos, F.; Scheel, A.; Holzman, S.; Dobbelstein, M. & Moll, U. M. (2011)
Cell Cycle, 10(4) pp. 680-689. DOI: https://doi.org/10.4161/cc.10.4.14859
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2010 | Journal Article |
Loss of p73 promotes dissemination of Myc-induced B cell lymphomas in mice
Nemajerova, A.; Petrenko, O.; Truemper, L. H.; Palacios, G. & Moll, U. M. (2010)
Journal of Clinical Investigation, 120(6) pp. 2070-2080. DOI: https://doi.org/10.1172/JCI40331
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